Mn(III) mixed-ligand complexes with bis-pyrazolones and ciprofloxacin drug: synthesis, characterization and antibacterial activities

摘要

The fluoroquinolone family member ciprofloxacin is well known for its drug design and coordinating ability towards metal ions. The coordination chemistry of this drug with metal ions of biological and pharmaceutical importance is of considerable interest. Novel Mn(III) mixed-ligand complexes of ciprofloxacin with various bis-pyrazolone-based dinegative bidentate ligands were synthesized and characterized on the basis of their physical properties, magnetic susceptibility measurements, (FT-IR and electronic) spectral studies. The FAB-mass spectrum of [Mn(A~9)(L)(H_2O)_2]-H_2O [where H_2A~9 = 4,4'-(p-tolylmethylene)bis{3-methyl-1-phenyl-4,5-dihydro-1H-pyrazol-5-ol)and HL=1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid] was determined. All the synthesized compounds were screened for their bioactivity. The mixed-ligand complexes exhibited comparable activities against two Gram-negative (Escherichia coli and Serratia marcescens) and two Gram-positive [Staphylococcus aureus and Bacillus subtilis) microorganisms.