HPNS seizure risk: an editorial perspective.

摘要

High pressure nervous syndrome was identified more than 40 years ago as a collection of well characterized signs and symptoms that can be attributed to the action of pressure on the central nervous system. Furthermore, this syndrome has been shown to be exhibited across the mammalian phylogenic tree with notable exceptions - the toothed whales and some species of seal Initial efforts to understand the syndrome revolved largely around the observation that pressure and general anesthetics appear to act as competitive antagonists. While this observation was of great practical value, driving the maximum depth attainable by human divers, from approximately 150 msw in the 1960s to 701 msw in the 1990s , it may in many ways have hindered the understanding of the action of pressure.