Palladium-catalyzed carbonylative cyclization of β-bromo-α,β-unsaturated carboxylic acids with primary amines leading to /V-alkylmaleimides

摘要

Cyclic β-bromo-α,β-unsaturated carboxylic acids are carbonylatively cyclized with primary amines under carbon monoxide pressure in MeCN in the presence of a catalytic amount of PdCI2(PPh3)2 to give N-alkylmaleimides.