Synthesis, structure and biological activity of diorganotin derivatives with pyridyl functionalized bis(pyrazol-1 -yl)methanes

摘要

Three pyridyl functionalized bis(pyrazol-1-yl)methanes, namely 2-[(4-pyridyl)methoxyphenyl] bis(pyrazol-1-yl)methane (L~1), 2-[(4-pyridyl)methoxyphenyl]bis(3,5-dimethylpyrazol-1-yI)methane (L~2) and 2-[(3-pyridyl)methoxyphenyl]bis(pyrazol-1-yl)methane (L~3) have been synthesized by the reactions of (2-hydroxyphenyl)bis(pyrazol-1 -yl)methanes with chloromethylpyri-dine. Treatment of these three ligands with R2SnCl2 (R = Et, n-Bu or Ph) yields a series of symmetric 2:1 adducts of (L)2SnR2CI2 (L = L~1, L~2 or L~3), which have been confirmed by elemental analysis and NMR spectroscopy. The crystal structures of (L~2)2Sn(n-Bu)2Cl2·0.5C6H_(14) and (L~3)2SnEt2Cl2 determined by X-ray crystallography show that the f unctionalized bis(pyrazol-1-yl)methane acts as a monodentate ligand through the pyridyl nitrogen atom, and the pyrazolyl nitrogen atoms do not coordinate to the tin atom. The cytotoxic activity of these complexes for Hela cells in vitro was tested.