Synthesis, characterization and cytotoxicity of Pt(II), Pd(ll), Cu(ll) and Zn(ll) complexes with 4'-substituted terpyridine

摘要

Eight novel Pt(II), Pd(I), Cu(II) and Zn(II) complexes with 4'-substituted terpyridine were synthesized and characterized by elemental analysis, UV, IR, NMR, electron paramagnetic resonance, high-resolution mass spectrometry and molar conductivity measurements. The cytotoxicity of these complexes against HL-60, BGC-823, KB and Bel-7402 cell lines was evaluated by MTT assay. All the complexes displayed cytotoxicity with low IC_(50) values (< 20 μm) and showed selectivity. Complexes 3, 5, 7 and 8 exerted 9-, 5-, 12- and 7-fold higher cytotoxicity than cisplatin against Bel-7402 cell line. The cytotoxicity of complexes 3,5,6,7 and 8 was higher than that of cisplatin against BGC-823 cell line. Complexes 3, 7 and 8 showed similar cytotoxicity to cisplatin against KB cell line. Complex 7 exhibited higher cytotoxicity than cisplatin against HL-60 cell line. Among these complexes, complex 7 demonstrated the highest in vitro cytotoxicity, with IC_(50) values of 1.62,3.59,2.28 and 0.63 μm against HL-60, BGC-823, Bel-7402 and KB cells lines, respectively. The results suggest that the cytotoxicity of these complexes is related to the nature of the terminal group of the ligand, the metal center and the leaving groups.