Synthesis and characterization of organotin complexes with dithiocarbamates and crystal structures of (4-NCC_6H_4CH_2)_2Sn(S_2CNEt_2)_2 and (2-ClC_6H_4CH_2)_2 Sn(Cl)S_2CNBz_2

摘要

Ten organotin derivatives with dithiocarbamates of the formulae (4-NCC_6H_4CH_2)_2Sn(S_2CNEt_2)_2 (1),(4-NCC_6H_4CH_2)_2Sn(S_2CNBz_2)_2 (2),(4-NCC_6H_4CH_2)_2Sn[S_2CN(CH_2CH_2)_2NCH_3]_2(3),(2-ClC_6H_4CH_2)_2 Sn(S_2CNEt_2)_2 (4),(2-ClC_6H_4CH_2)_2Sn(S_2CNBz_2)_2 (5),(4-NCC_6H_4CH_2)_2Sn(Cl)S_2CNEt_2 (6),(4-NCC_6H_4CH_2)_2Sn(Cl)S_2CNBz_2 (7),(4-NCC_6H_4CH_2)_2Sn(Cl)S_2CN(CH_2CH_2)_2NCH_3 (8),(2-ClC_6H_4CH_2)_2 Sn(Cl)S_2CNEt_2 (9) and (2-ClC_6H_4CH_2)_2Sn(Cl)S_2CNBz_2 (10) have been prepared.All complexes were characterized by elemental analyses,IR and NMR.The crystal structures of complexes 1 and 10 were determined by X-ray single crystal diffraction.For complex 1,the central tin atom exists in a skew-trapezoidal planar geometry defined by two asymmetrically coordinated dithiocarbamate ligands and two 4-cyanobenzyl groups.In addition,because of the presence of close intermolecular non-bonded contacts,complex 1 is a weakly-bridged dimer.In complex 10,the central tin atom is rendered pentacoordinated in a distorted trigonal bipyramidal configuration by coordinating with S atoms derived from the dithiocarbamate ligand.In vitro assays for cytotoxicity against five human tumor cell lines (MCF-7,EVSA-T,WiDr,IGROV and M226) furnished the significant toxicities of the title complexes.