Effective Chiral Ferrocenyl Phosphine-Thioether Ligands in Enantioselective Palladium-Catalyzed Allylic Alkylations

摘要

Chiral ferrocene-derived phosphine-thio-ether mixed donor ligands supported by heterocycles effected the palladium-catalyzed enantioselective al-lylic alkylations with excellent yields and enantiose-lectivities (up to 96% ee). With cyclic and unsymmet-rical allylic acetates as substrate, the corresponding alkylated products with enantioselectivities up to 87% ee were obtained. Based on X-ray crystallo-graphic and NMR studies, the origin of the observed enantioselectivities is discussed.