Generation of 11-Fluoro-11H-indeno[1,2-c]quinolines via a Palladium-Catalyzed Three-Component Reaction of 2-Alkynylbromobenzenes, 2-Alkynylanilines, and N-Fluorobenzenesulfonimide

摘要

A novel and efficient synthesis of 11-fluoro-11H-indeno[l,2-c]quinolines has been developed via a palladium-catalyzed three-component reaction of 2-alkynylbromobenzenes, 2-alkynylanilines, and N-fluorobenzenesulfonimide. The reaction works well with high selectivity. Additionally, the diversity and complexity could be easily introduced via a simple operation from readily available startingmaterials. In the meantime, a fluorine atom could be incorporated into the scaffold during the reaction process.