Vanadium-Catalyzed Enantioselective Sulfoxidation and Concomitant,Highly Efficient Kinetic Resolution Provide High Enantioselectivity and Acceptable Yields of Sulfoxides

摘要

Simple,inexpensive,preformed vanadium-Schiff base complexes were facilely prepared and used in enantioselective sulfoxidation.Both the amount of aqueous H_2O_2 and reaction time greatly influenced the ee values and yields of chiral sulfox-ides.High enantioselectivities (up to 99% ee) and reasonable yields (> 40%) for various chiral sulfox-ides were achieved by combining enantioselective sulfoxidation and appropriate concomitant kinetic resolution.