Ligand-Free Copper-Manganese Spinel Oxide-Catalyzed Tandem One-Pot C-H Amidation and N-Arylation of Benzylamines: A Facile Access to 2-Arylquinazolin-4(3H)-ones

摘要

An efficient ligand-free copper-manganese (Cu-Mn) spinel oxide-catalyzed direct tandem C-H oxygenation and N-arylation of benzylamines has been developed. The method has been utilized for the synthesis of medicinally important 2-arylqui-nazolin-4(3H)-ones. Salient features of this method include recyclable catalyst, no ligand, excellent product yields, shorter reaction times and a broad substrate scope.