A Cooperative Catalytic System of Platinum/Indium Alloyed Nanoclusters and a Dimeric Catechol Derivative: An Efficient Synthesis of Quinazolines Through a Sequential Aerobic Oxidative Process

摘要

A cooperative catalytic system of heterogeneous polymer-supported bi-metallic platinum/iri-dium (Pt/Ir) alloyed nanoclusters and 5,5',6,6'-tetra-hydroxy-3,3,3',3'-tetramethyl-l,l'-spiro-bisindane (TTSBI) enabled the facile preparation of quinazo-line derivatives with low catalyst loadings and broad substrate scope under mild aerobic oxidative conditions. The ability to perform the reaction in gram-scale and under open-air conditions highlights the synthetic application of this cooperative catalytic system.