Indium(III) Chloride-Catalyzed Propargylation/Amination/Cyclo- isomerization Tandem Reaction: One-Pot Synthesis of Highly Substituted Pyrroles from Propargylic Alcohols, 1,3-Dicarbonyl Compounds and Primary Amines

摘要

A convenient one-pot propargylation/ami-nation/cycloisomerization tandem process has been developed for the synthesis of highly substituted pyrroles derivatives from propargylic alcohols, 1,3-dicar-bonyl compounds and primary amines using indium-(III) chloride as a multifunctional catalyst. This method provides a flexible and rapid route to substituted pyrroles.