Biocatalytic Racemization of alpha-Hydroxy Ketones(Acyloins)at Physiological Conditions using Lactobacillus paracasei DSM 20207

摘要

Biocatalytic racemization of open-chain and cyclic dialkyl-,alkyl-aryl-and diaryl-substituted acyloins was accomplished using whole resting cells of Lactobacillus paracasei DSM 20207.The mild(physiological)reaction conditions ensured the suppression of undesired side reactions,such as elimination or condensation.This novel biocatalytic isomer-ization protocol represents an essential tool for the deracemization of pharmacologically important building blocks.