Assessment: symptomatic treatment for muscle cramps (an evidence-based review): report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology.

摘要

Very-low-dose clonazepam, a benzodiazepine, is our choice for treating PMCs (e.g., in peripheral neuropathy or amyotrophic lateral sclerosis), which are generated by a disturbance anywhere in the lower motor neuron: soma, axon-Schwann cell complex, or distal axonal twigs. PMCs are often worse at the end of an especially active day or during that night. They can cause "painful insomnia" (difficulty achieving sleep and awakening during sleep).