Manganese Dioxide-Mediated Oxidative Coupling of 1,3-Dicarbonyl Compounds with α,β-Unsaturated Ketones: Direct Access to 3,4-DicarbonyI Substituted Furans

摘要

An efficient manganese dioxide-mediated and highly selective oxidative C—H/C—H functional-ization of 1,3-dicarbonyl compounds with α,β-unsa-turated ketones for the construction of tetrasubsti-tuted furans in one step has been demonstrated. This catalytic system converts two C—H bonds and G=O bonds to C=C and C—O bonds. This reaction provides a facile and regio-defined method for the synthesis of 3,4-dicarbonyl substituted furans.