Construction of Trifluoromethyl-Bearing Quaternary Carbon Centers by Intramolecular Decarboxylative Allylation of α-Trifluoromethyl β-Keto Esters

摘要

A new palladium-catalyzed decarboxyla-tive allylation of allyl α-trifluoromethyl-|3-keto esters was developed in the presence of tris(dibenzyli-deneacetone)dipalladium [Pd2(dba)3] and l,2-bis(di-phenylphosphino)ethane (dppe) in tetrahydrofuran. α-Trifluoromethyl ketones featuring a quaternary carbon center were produced in good yields and the dreaded α,β-unsaturated-β,β-difluoro ketones resulting from β-elimination of a fluoride ion was not observed.