Recent Advances in Asymmetric C-C and C-Heteroatom Bond Forming Reactions using Polymer-Bound Catalysts

摘要

The synthesis of enantiomerically pure compounds is one of the major challenges in organic synthesis. In the review, we present the state of the art in asymmetric catalysis using immobilized chiral ligands and complexes for asymmetric C-C and C-heteroatom bond forming reactions. Chiral catalysts based on dendrimers and soluble polymeric supports are considered. In particular, addition reactions to carbon-carbon double bonds, asymmetric 1,2-addition reactions using, e.g., dialkylzinc reagents, metalcatalyzed substitution reactions and cylcloaddition reactions are covered. Specific emphasis is placed on enantioselective epoxidation and aldol reactions. A further aspect is the (hetero) Diels-Alder reaction catalyzed by immobilized ligands.