Olfaction in Parkin-associated Parkinson disease: another enigma.

摘要

Impairment of olfactory function is commonly seen in neurodegenerative diseases such as Parkinson disease (PD), Alzheimer disease, and Huntington disease, but also occurs during normal aging. Therefore, it is not too surprising that in sporadic PD (SPD), olfactory impairment can appear both before and after the onset of motor dysfunction. Nonetheless, in PD, the severity of the olfactory impairment seems to correlate with the severity of motor symptoms, although not in a linear fashion.