New Carbohydrate-Based Phosphite-Oxazoline Ligands as Highly Versatile Ligands for Palladium-Catalyzed Allylic Substitution Reactions

摘要

We have designed and synthesized a new family of readily available phosphite-oxazoline li-gands for Pd-catalyzed asymmetric allylic substitution reactions.These ligands can be tuned in two regions to explore their effect on catalytic performance.By carefully selecting the ligand components,we obtained high enantioselectivities in the Pd-catalyzed allylic substitution in substrates with different steric properties