Enantioselective N-Heterocyclic Carbene-Catalyzed [3+3] Annulation of ,-Unsaturated Esters with Methyl Ketoimine

摘要

Herein, we disclose the N-heterocyclic carbene (NHC)-catalyzed [3+3] annulation of challenging esters with methyl ketoimines for the highly enantioselective synthesis of intriguing -lactams featuring various substituent patterns. The annulation occurs under mild conditions and offers good tolerance, good yields and excellent enantioselectivities. The six-membered heterocyclic products are valuable for the synthesis of bioactive molecules.