Organocatalytic Asymmetric C-S Bond Formation: Synthesis of α-Methylene-β-mercapto Esters with Simple Alkyl Thiols

摘要

A highly efficient organocatalytic enan-tioselective C-S bond formation reaction between simple alkyl thiols and Morita-Baylis-Hillman (MBH) carbonates is described. The optically active a-methylene |3-mercapto esters could be obtained under mild reaction conditions with excellent enantioselectivities (up to 97% ee). The broad scope and simple operation make this methodology very practical.