Distribution of Amphotericin B-Arabinogalactan Conjugate in Mouse Tissue and Its Therapeutic Efficacy against Murine Aspergillosis.

Falk R; Grunwald J; Hoffman A; Domb AJ; Polacheck I

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Distribution of Amphotericin B-Arabinogalactan Conjugate in Mouse Tissue and Its Therapeutic Efficacy against Murine Aspergillosis.

机译：两性霉素B-阿拉伯半乳聚糖缀合物在小鼠组织中的分布及其对鼠曲霉病的治疗作用。

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摘要

The pharmacokinetic characteristics and tissue distribution of a novel water-soluble, nontoxic amphotericin B-arabinogalactan (AMB-AG) conjugate exhibited distinct differences from those of micellar and liposomal amphotericin B formulations. These differences included extended persistence of drug in the body and its accumulation in the lungs; thus, the AMB-AG conjugate was highly effective in treating systemic murine aspergillosis.

机译：新型水溶性，无毒的两性霉素B-阿拉伯半乳聚糖（AMB-AG）偶联物的药代动力学特征和组织分布与胶束和脂质体两性霉素B制剂表现出明显的差异。这些差异包括药物在体内的持久性及其在肺中的积累;因此，AMB-AG缀合物在治疗全身性鼠曲霉病中非常有效。

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《Antimicrobial agents and chemotherapy.》 |2004年第9期|共4页
作者
Falk R; Grunwald J; Hoffman A; Domb AJ; Polacheck I;
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正文语种 eng
中图分类药学;
关键词
Aspergillosis; Amphotericin B; Therapeutic brand of coal tar; Murine; Conjugate; 曲霉病; 两性霉素B;

机译：Aspergillosis;Amphotericin B;Therapeutic brand of coal tar;Murine;Conjugate;曲霉病;两性霉素B;

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1. Distribution of Amphotericin B-Arabinogalactan Conjugate in Mouse Tissue and Its Therapeutic Efficacy against Murine Aspergillosis. [J] . Falk R, Grunwald J, Hoffman A, Antimicrobial agents and chemotherapy. . 2004,第9期

机译：两性霉素B-阿拉伯半乳聚糖缀合物在小鼠组织中的分布及其对鼠曲霉病的治疗作用。
2. Toxicity and therapeutic efficacy of amphotericin B delivered through cholesterol hemisuccinate vesicles in the treatment of experimental murine aspergillosis. [J] . Saxena S, Khan JA, Ghosh PC The Journal of Antimicrobial Chemotherapy . 1998,第5期

机译：通过胆固醇半琥珀酸盐囊泡递送的两性霉素B的毒性和治疗功效在实验性鼠曲霉病的治疗中。
3. Therapeutic efficacy of a 177Lu-labeled DOTA conjugated alpha-melanocyte-stimulating hormone peptide in a murine melanoma-bearing mouse model. [J] . Miao Y, Shelton T, Quinn TP Cancer biotherapy and radiopharmaceuticals . 2007,第3期

机译：177Lu标记的DOTA缀合的α-黑素细胞刺激激素肽在小鼠黑素瘤小鼠模型中的治疗功效。
4. Efficacy of amphotericin b cochleate in a murine model: comparison to micellar and liposomal amb formulations [C] . J.R.Graybill, L.K.Najvar, R.Bocanegra, International symposium on controlled release of bioactive materials;Consumer and diversified products conference . 2000

机译：两性霉素b耳蜗在小鼠模型中的功效：与胶束和脂质体抗体配方的比较
5. Investigations of the biodistribution and phototherapeutic utility of two palladium(II)-containing macrocyclic drugs in a tumour-bearing mouse model: A study of the pharmacokinetics and tissue distribution of the potential photodynamic drug palladium-bacteriopheophorbide as well as the in vivo treatment efficacy and tissue distribution of the potential photothermal drug palladium(II) octabutoxynaphthalocyanine. [D] . DeGroot, Jennifer Leanne. 2002

机译：两种含钯（II）的大环药物在荷瘤小鼠模型中的生物分布和光疗实用性的研究：潜在的光动力药物钯-细菌脱镁叶绿酸的药代动力学和组织分布以及体内治疗效果和研究光热药物钯（II）八丁氧基萘酞菁的组织分布。
6. Distribution of Amphotericin B-Arabinogalactan Conjugate in Mouse Tissue and Its Therapeutic Efficacy against Murine Aspergillosis [O] . Rama Falk, Jacob Grunwald, Amnon Hoffman, 2004

机译：两性霉素B-阿拉伯半乳聚糖缀合物在小鼠组织中的分布及其对鼠曲霉病的治疗作用
7. Distribution of Amphotericin B-Arabinogalactan Conjugate in Mouse Tissue and Its Therapeutic Efficacy against Murine Aspergillosis [O] . Falk, Rama, Grunwald, Jacob, Hoffman, Amnon, 2004

机译：两性霉素B-阿拉伯半乳聚糖缀合物在小鼠组织中的分布及其对鼠曲霉病的治疗作用

Distribution of Amphotericin B-Arabinogalactan Conjugate in Mouse Tissue and Its Therapeutic Efficacy against Murine Aspergillosis.

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