Anti-hepatitis B virus activity of ORI-9020, a novel phosphorothioate dinucleotide, in a transgenic mouse model.

Iyer RP; Roland A; Jin Y; Mounir S; Korba B; Julander JG; Morrey JD

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Anti-hepatitis B virus activity of ORI-9020, a novel phosphorothioate dinucleotide, in a transgenic mouse model.

机译：ORI-9020（一种新型的硫代磷酸二核苷酸）在转基因小鼠模型中的抗乙型肝炎病毒活性。

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ORI-9020, a novel dinucleotide, evaluated in transgenic mice expressing hepatitis B virus (HBV), significantly reduced liver HBV DNA (P

机译：在表达乙型肝炎病毒（HBV）的转基因小鼠中评估的ORI-9020是一种新型二核苷酸，可显着降低肝脏HBV DNA（P≤0.001）。血清HBeAg和HBsAg的水平以及肝脏HBcAg的水平不受治疗的影响。确定的最小有效剂量为1.6至0.5 mg / kg体重/天，这与阿德福韦酯的观察到的相似。

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《Antimicrobial agents and chemotherapy.》 |2004年第6期|共3页
作者
Iyer RP; Roland A; Jin Y; Mounir S; Korba B; Julander JG; Morrey JD;
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正文语种 eng
中图分类药学;
关键词
novel; Laboratory mice; Hepatitis B Virus; Dinucleoside Phosphates; phosphorothioate; 肝炎病毒; 乙型; 二核苷磷酸类;

机译：novel;Laboratory mice;Hepatitis B Virus;Dinucleoside Phosphates;phosphorothioate;肝炎病毒;乙型;二核苷磷酸类;

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1. Anti-hepatitis B virus activity of ORI-9020, a novel phosphorothioate dinucleotide, in a transgenic mouse model. [J] . Iyer RP, Roland A, Jin Y, Antimicrobial agents and chemotherapy. . 2004,第6期

机译：ORI-9020（一种新型的硫代磷酸二核苷酸）在转基因小鼠模型中的抗乙型肝炎病毒活性。
2. Oral poliovirus vaccine type 3 from a patient with transverse myelitis is neurovirulent in a transgenic mouse model. [J] . Thorley B, Kelly H, Nishimura Y, Journal of clinical virology: The official publication of the Pan American Society for Clinical Virology . 2009,第4期

机译：患有横贯性脊髓炎的患者的口服脊髓灰质炎疫苗3型在转基因小鼠模型中具有神经毒性。
3. Effect of interferon alpha and cell cycle progression on translation mediated by the hepatitis C virus 5' untranslated region: a study using a transgenic mouse model. [J] . Takeda Y, Okoshi S, Suzuki K, Journal of viral hepatitis. . 2004,第1期

机译：干扰素α和细胞周期进程对丙型肝炎病毒5'非翻译区介导的翻译的影响：一项使用转基因小鼠模型的研究。
4. In vitro anti-hepatitis B virus activity of konjac oligo-glucomannan sulfate [C] . Huang Hao, Yang Zhonghua, Wang Guanghui, 2010 3rd International Conference on Biomedical Engineering and Informatics . 2010

机译：魔芋寡糖甘露聚糖硫酸盐的体外抗乙肝病毒活性
5. Adenovirus- and cationic-lipid-mediated intratumoral gene transfer and natural killer cell activity in a SCID mouse melanoma tumor model. [D] . Clark, Paul Robert. 1999

机译：在SCID小鼠黑素瘤肿瘤模型中，腺病毒和阳离子脂质介导的肿瘤内基因转移和自然杀伤细胞活性。
6. Anti-Hepatitis B Virus Activity of ORI-9020 a Novel Phosphorothioate Dinucleotide in a Transgenic Mouse Model [O] . Radhakrishnan P. Iyer, Arlene Roland, Yi Jin, 2004

机译：ORI-9020一种新型的硫代磷酸二核苷酸在转基因小鼠模型中的抗乙型肝炎病毒活性
7. Anti-Hepatitis B Virus Activity of ORI-9020, a Novel Phosphorothioate Dinucleotide, in a Transgenic Mouse Model [O] . Iyer, Radhakrishnan P., Roland, Arlene, Jin, Yi, 2004

机译：ORI-9020，一种新型的硫代磷酸二核苷酸，在转基因小鼠模型中的抗乙型肝炎病毒活性
8. Role of the 5HT3 Receptor in Alcohol Drinking and Aggression Using A Transgenic Mouse Model. [R] . Allan, A. M. 2005

机译：使用转基因小鼠模型研究5HT3受体在酒精饮用和侵袭中的作用。

Anti-hepatitis B virus activity of ORI-9020, a novel phosphorothioate dinucleotide, in a transgenic mouse model.

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