Reactive Oxygen Intermediates and Signaling Through Kinase Pathways

摘要

CELLS, WHETHER PHOKARYOTE, ANIMAL, OR PLANT, have evolved under the constant stress of oxygen radicals. Oxygen radicals can be generated in cells via both respiration and photosynthesis (3, 8). In addition, UV light, triggering of certain cell-surface receptors, and exposure to a variety of chemicals will result in the generation of intracellular oxygen radicals (11, 16, 36, 39). Extrinsic exposure to reactive oxygen intermediates also can occur (15). Oxygen intermediates can be harmful to the cell, as they can damage DNA, proteins, and lipids (34)