Iron overload indices rise linearly with transfusion rate in patients with sickle cell disease.

摘要

We read with interest the article by Adamkiewicz et al wherein the authors showed that serum ferritin (SF) level and liver iron concentration (LIC) do not rise linearly with transfusion load as measured by total number of transfusions received or transfusion iron load (TIL). We herein hypothesize that if the authors had considered transfusion rate instead of transfusion load, a more linear correlation may be found.