Leukemia takes center (late) stage

摘要

In this issue of Blood, Newrzela and colleagues present experiments that show how-mature T lymphocytes are resistant to transformation by retrovirally transduced T-cell oncogenes.The 3 oncogenes induced leukomas in recipients of transduced HSCs, but the recipients of transduced mature T cells did not develop disease. Transduced lymphocytes were transplanted again into secondary irradiated recipients and no leukemia was seen, even though there was high-level expression of the transgenes and prolonged in vivo observation, up to 1 year in some serial transplant experiments. Integration site analysis did not show clonal selection that would suggest preleifite-mic hyperplasia in the secondary transplanted mature T cells. Too few retroviral insertions were cloned for comparison of HSCs versus mature T-cell integration patterns.