Molecular mechanism of flucytosine resistance in Candida lusitaniae: contribution of the FCY2, FCY1, and FUR1 genes to 5-fluorouracil and fluconazole cross-resistance.

Papon N; Noel T; Florent M; Gibot-Leclerc S; Jean D; Chastin C; Villard J; Chapeland-Leclerc F

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Molecular mechanism of flucytosine resistance in Candida lusitaniae: contribution of the FCY2, FCY1, and FUR1 genes to 5-fluorouracil and fluconazole cross-resistance.

机译：Lusitaniae中氟胞嘧啶抗性的分子机制：FCY2，FCY1和FUR1基因对5-氟尿嘧啶和氟康唑交叉耐药性的贡献。

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Inactivation of the FCY2 (cytosine permease), FCY1 (cytosine deaminase), and FUR1 (uracil phosphoribosyltransferase) genes in Candida lusitaniae produced two patterns of resistance to flucytosine. Mutant fur1 demonstrated resistance to 5-fluorouracil, whereas mutants fcy1 and fcy2 demonstrated fluconazole resistance in the presence of subinhibitory flucytosine concentrations.

机译：Lusitaniae假丝酵母中FCY2（胞嘧啶通透酶），FCY1（胞嘧啶脱氨酶）和FUR1（尿嘧啶磷酸核糖转移酶）基因的失活产生了两种对氟胞嘧啶的抗性模式。突变体fur1表现出对5-氟尿嘧啶的抗性，而突变体fcy1和fcy2在存在亚抑制性氟胞嘧啶浓度的情况下表现出对氟康唑的抗性。

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《Antimicrobial agents and chemotherapy.》 |2007年第1期|共3页
作者
Papon N; Noel T; Florent M; Gibot-Leclerc S; Jean D; Chastin C; Villard J; Chapeland-Leclerc F;
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正文语种 eng
中图分类治疗学;
关键词
Alleles; Antifungal Agents; Candida; Cloning; Molecular; Cytosine Deaminase; 等位基因; 抗真菌药; 念珠菌属; 克隆; 分子; DNA; 真菌; 氟康唑; 氟胞嘧啶; 氟尿嘧啶;

机译：Alleles;Antifungal Agents;Candida;Cloning;Molecular;Cytosine Deaminase;等位基因;抗真菌药;念珠菌属;克隆;分子;DNA;真菌;氟康唑;氟胞嘧啶;氟尿嘧啶;

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1. Molecular mechanism of flucytosine resistance in Candida lusitaniae: contribution of the FCY2, FCY1, and FUR1 genes to 5-fluorouracil and fluconazole cross-resistance. [J] . Papon N, Noel T, Florent M, Antimicrobial agents and chemotherapy. . 2007,第1期

机译：Lusitaniae中氟胞嘧啶抗性的分子机制：FCY2，FCY1和FUR1基因对5-氟尿嘧啶和氟康唑交叉耐药性的贡献。
2. Nonsense and missense mutations in FCY2 and FCY1 genes are responsible for flucytosine resistance and flucytosine-fluconazole cross-resistance in clinical isolates of Candida lusitaniae. [J] . Florent M, Noel T, Ruprich Robert G Antimicrobial agents and chemotherapy. . 2009,第7期

机译：FCY2和FCY1基因中的无义和错义突变是导致卢丝假丝酵母临床分离株中氟胞嘧啶耐药和氟胞嘧啶-氟康唑交叉耐药的原因。
3. Inactivation of the FCY2 gene encoding purine-cytosine permease promotes cross-resistance to flucytosine and fluconazole in Candida lusitaniae. [J] . Chapeland Leclerc F, Bouchoux J, Goumar A, Antimicrobial agents and chemotherapy. . 2005,第8期

机译：编码嘌呤-胞嘧啶通透酶的FCY2基因的失活促进了卢丝假丝酵母对氟胞嘧啶和氟康唑的交叉耐药性。
4. (667d) Carbohydrate Circle and Genetic Information Flow Studies of Escherichia Coli Reveal the Molecular Mechanisms of Resistance to Balofloxacin [C] . Xtian-Xian Peng1, Jian-Yi Pan2, Hong-Kai Wu1, American Institute of Chemical Engineers annual meeting . 2010

机译：（667D）大肠杆菌的碳水化合物圈和遗传信息流程研究揭示了抗白菜氧化嘧啶的分子机制
5. Molecular mechanisms of FOXP3-mediated gene regulation and their contribution to T cell and thymic epithelial cell function. [D] . Hench, Virginia K. 2010

机译：FOXP3介导的基因调控的分子机制及其对T细胞和胸腺上皮细胞功能的贡献。
6. Molecular Mechanism of Flucytosine Resistance in Candida lusitaniae: Contribution of the FCY2 FCY1 and FUR1 Genes to 5-Fluorouracil and Fluconazole Cross-Resistance [O] . Nicolas Papon, Thierry Noël, Martine Florent, 2007

机译：Lusitaniae中氟胞嘧啶抗性的分子机制：FCY2FCY1和FUR1基因对5-氟尿嘧啶和氟康唑交叉耐药性的贡献。
7. Molecular mechanism of flucytosine resistance in Candida lusitaniae: contribution of the FCY2, FCY1, and FUR1 genes to 5-fluorouracil and fluconazole cross-resistance. [O] . Papon, Nicolas, Noël, Thierry, Florent, Martine, 2007

机译：Lusitaniae中氟胞嘧啶抗性的分子机制：FCY2，FCY1和FUR1基因对5-氟尿嘧啶和氟康唑交叉耐药的贡献。

Molecular mechanism of flucytosine resistance in Candida lusitaniae: contribution of the FCY2, FCY1, and FUR1 genes to 5-fluorouracil and fluconazole cross-resistance.

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