Lack of association between CCND1 G870A polymorphism and the risk of breast and colorectal cancers.

摘要

BACKGROUND: The aim of this case-control study was to investigate whether the common G870A polymorphism in the Cyclin D1 gene (CCND1) is a risk factor for breast and colorectal cancers in an Australian population. PATIENTS AND METHODS: A total of 339 breast and 569 colorectal cancer cases were studied, together with 327 age-matched controls. Genotyping for the G870A polymorphism in CCND1 was carried out using single strand conformation polymorphism and Pyrosequencing methods. RESULTS: Comparison of the CCND1 G870A genotype frequencies revealed no significant associations between presence of the A allele and the risk of either breast or colorectal cancer. No associations were noted between presence of the A allele and pathological features of these tumours or patient survival. CONCLUSION: Although the CCND1 G870A polymorphism has been reported as a genetic risk factor for some tumour types, it does not appear to be linked to the risk of breast and colorectal cancers.