Posaconazole therapy of disseminated phaeohyphomycosis in a murine model.

摘要

Immunocompetent (nu/+) and athymic (nuu) BALB/c mice were infected intravenously with Wangiella dermatitidis and treated with posaconazole. Posaconazole reduced the counts in tissues and prolonged survival. Of particular interest, posaconazole reduced the counts of this neurotropic pathogen in the brain.