Lifestyle and adiponectin level: four-year follow-up of controlled trials.

摘要

The adiponectin adipocyte-secreted adipokine has both insulin-enhancer and anti-inflammatory properties and is the most consistent biochemical predictor of type 2 diabetes mellitus. Higher adiponectin levels are consistently associated with a lower risk of type 2 diabetes in 13 prospective studies of diverse populations with a total of 14 598 participants and 2623 incident cases of type 2 diabetes, with a relative risk of 0.72 (95% confidence interval, 0.67-0.78) per 1-logug/mL increment in adiponectin levels. Identification of lifestyle changes able to increase adiponectin circulating levels may help refine the strategy against the current diabetes epidemics.