Long-term renal outcomes of patients with type 1 diabetes mellitus and microalbuminuria: an analysis of the DCCT/EDIC cohort.

摘要

In the March 14,2011, issue of the Archives, de Boer et al characterize long-term renal outcomes in patients with type 1 diabetes mellitus (T1DM) and mi-croalbuminuria from the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) study. The data indicate that, within 10 years after commencement of microal-buminuria in patients with T1DM, 40% of patients will regress to normoalbuminuria and 47% of patients will progress to severe nephropathy. After rigorous statistical analysis, the authors identified several clinical factors that were associated with favorable microalbumin-uria outcomes such as lower blood pressure, lower glycated hemoglobin level, absence of retinopathy, and favorable lipid profile. We would like to note that the authors have not discussed several facts learned from genetic analyses of T1DM studies including the DCCT study that could be worth mentioning.