Fatal lung toxic effects related to dronedarone use

摘要

Dronedarone is a derivative of amiodarone that aimed to reduce the extracardiac adverse effects while preserving its antiarrhythmic effects for treatment of atrial fibrillation (AF).1 In the ATHENA trial (A Placebo-Controlled, Double-Blind, Parallel Arm Trial to Assess the Efficacy of Dronedarone 400 mg bid for the Prevention of Cardiovascular Hospital-ization or Death from Any Cause in Patients with Atrial Fibrillation/Atrial Flutter),2 dronedarone reduced cardiovascular hospitalization and death in patients widi non-permanent atrial fibrillation (AF) with other cardiovascular risk factors. However, an experimental study3 suggested that dronedarone might have toxic effects on the lung greater than or equal to amiodarone.