Systems Vaccinomics: The Road Ahead for Vaccinology

摘要

In 1985, an Institute of Medicine report (Division of Health Promotion and Disease Prevention and Institute of Medicine, 1985) stated: "Vaccines are an elegant solution to one of the perennial problems of the human race—infectious disease. The body's own protective mechanisms are primed by specific interventions to thwart the invasion of or multiplication of pathogenesis." Vaccines are indeed one of the great triumphs of modern medicine and public health: they prevent disease, they are relatively inexpensive, easy to deliver and their effects long lasting, and their mechanism of action relies entirely on activation of our body's own protective immunological mechanisms.