WHO classification of myeloid neoplasms and leukemia.

摘要

Vardiman et al have focused their paper1 on major changes in the 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and leukemia compared with the 2001 edition and have provided the rationale for those changes. Many of these changes and new definitions follow biologic features and include important information for prognosis. They pave the way not only to a better understanding of acute myeloid leukemia (AML) but also will advance outcome for patients. However, we cannot agree with the rationale for maintaining the category of "acute myeloid leukemia with multilineage dyspla-sia" (MLD), first established in the third edition in 2001, that is now subgrouped in the group of "AML with myelodysplasia-related changes.