Plerixafor-moblized stem cells alone are capable of inducing early engraftment across the MHC-haploidentical canine barrier.

摘要

Donahue and colleagues published in Blood a study comparing CD34~+ cells mobilized by plerixafor (AMD3100) or granulocyte colony-stimulating factor (G-CSF) in macaques. Different gene profiling patterns and cell types were produced based on mobilization protocol. The authors postulated that these differences could influence engraftment and toxicity profiles in clinical hematopoi-etic cell transplantation (HCT).