Alloimmunization to red blood cell antigens by transfusion.

摘要

In their impressive report in a previous issue of Blood, Higgins and Sloan examined large patient databases and developed a model of alloimmunization to red blood cell antigens as a stochastic process. They identified a subgroup of recipients that had a substantially increased risk of alloimmunization that was independent of common disease states, age, or number of alloantibodies previously formed. Their model suggests that approximately 13% of the transfusion recipient population are responders and at risk of forming red blood cell alloantibodies.