Validation of alternative methods of preparing Tc-99m-MAG3

摘要

Parameters in the preparation of Tc-99m-mertiatide (Tc-99m-MAG3) were investigated to determine the importance of total activity, activity concentration, boiling time, and delay before boiling for the radiochemical purity (RCP) and stability of the product. Satisfactory RCP results (> 90%) were obtained over a range of concentrations including a dilute preparation for paediatric use. RCP was not affected by the time between the addition of pertechnetate and boiling, but low RCP (< 60%) resulted when the kit was boiled for less than 10 min. (c) 2007 Elsevier Ltd. All rights reserved.