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Validation of alternative methods of preparing Tc-99m-MAG3

机译:验证制备Tc-99m-MAG3的替代方法

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摘要

Parameters in the preparation of Tc-99m-mertiatide (Tc-99m-MAG3) were investigated to determine the importance of total activity, activity concentration, boiling time, and delay before boiling for the radiochemical purity (RCP) and stability of the product. Satisfactory RCP results (> 90%) were obtained over a range of concentrations including a dilute preparation for paediatric use. RCP was not affected by the time between the addition of pertechnetate and boiling, but low RCP (< 60%) resulted when the kit was boiled for less than 10 min. (c) 2007 Elsevier Ltd. All rights reserved.
机译:研究了制备Tc-99m-巯基乙二胺(Tc-99m-MAG3)的参数,以确定总活性,活性浓度,沸腾时间和沸腾延迟对放射化学纯度(RCP)和产品稳定性的重要性。在一定浓度范围内(包括用于儿科的稀释制剂)获得了令人满意的RCP结果(> 90%)。 RCP不受高tech酸盐添加到沸腾之间的时间的影响,但是当试剂盒煮沸少于10分钟时,RCP较低(<60%)。 (c)2007 Elsevier Ltd.保留所有权利。

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