MALT lymphoma-derived rheumatoid factors are nonpolyreactive high-affinity antibodies.

摘要

We have read with particular interest the paper of Craig et al, describing that 6 of 7 human mucosa-associated lymphoid tissue (MALT) lymphoma-derived immunoglobulins (Igs) bound various antigens with intermediate affinity, thus implying that MALT lymphomas express polyreactive antigen receptors. We previously reported that MALT lymphomas frequently express Igs, which are homologous to canonical rheumatoid factors (RFs), encoded by Vl-69-JH4/Vk3-20 and V3-7-JH3/Vk3-15 IgVH/IgVk rearrangements and that recombinant Igs derived of these MALT lymphomas indeed bound human IgG. Interestingly, we noticed that the panel of MALT lymphoma Igs produced by Craig et al also contained 3 cases with homology to Vl-69 RFs (hu-1 and hu-7) and V3-7 RFs (hu-2), although it is noted that 2 of these MALT lymphoma RFs (ie hu-2 and hu-7) were not coexpressed with the canonical Vk3-20 and Vk3-15 genes as described in literature of 14 of 14 Vl-69 RF and of 10 of 10 V3-7 RF cases, respectively.