Hydroxyapatite (HA) microparticles labeled with P-32 - A promising option in the radiation synovectomy for inflamed joints

摘要

In the present article we describe a systematic approach pursued for the synthesis of P-32-labeled hydroxyapatite (HA) microparticles (1-10 mu m size range) using no carrier added (NCA) P-32 produced in a nuclear reactor and animal evaluation of its utility as an expected viable radiopharmaceutical for the treatment of pain intensive arthrosis. NCA P-32 was produced via the S-32(n,p)P-32 route in nuclear reactor with high radionuclidic purity (99.95 +/- 0.01%, n=5). Phosphorus-32-labeled hydroxyapatite micro particles (1-10 mu m size range) were synthesized with high radiochemical purity (99.0 +/- 0.3% n=12) under optimized conditions and the, formulation showed excellent in vitro stability in saline as well as in rat serum. Intra-articular administration of the radiolabeled particles in the knee joints of normal Wistar rats showed near-complete retention of activity within the synovial cavity upto 1 month post-administration. The radiochemical formulation thus demonstrated promising features as a radiopharmaceutical for treatment of arthritis with excellent logistic advantage for shipment to sites distant from the production facility thanks to the suitable nuclear decay properties of P-32. (C) 2016 Elsevier Ltd. All rights reserved.