Cation exchange-based post-processing of Ga-68-eluate: A comparison of three solvent systems for labelling of DOTATOC, NO2AP(BP) and DATA(m)

摘要

Interest in Ga-68 has led to a number of innovations for its provision suitable for clinical application. Several post-processing methods are available to reduce eluate volume and remove metal trace impurities. In this work three cation exchange resin based post-processing methods (acetone, ethanol and NaCl) have been compared, using three model precursors (DOTATOC, NO2AP(BP) and DATA(m)), in terms of labelling yield and reproducibility. The acetone and ethanol based methods provided greater reproducibility and yields that makes subsequent purification unnecessary. (C) 2015 Elsevier Ltd. All rights reserved.