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首页> 外文期刊>Applied radiation and isotopes: including data, instrumentation and methods for use in agriculture, industry and medicine >Development of 'leaky' liposome triggered by radiation applicable to a drug reservoir and a simple radiation dosimeter
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Development of 'leaky' liposome triggered by radiation applicable to a drug reservoir and a simple radiation dosimeter

机译:辐射触发的“泄漏”脂质体的开发适用于药物储库和简单的辐射剂量计

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摘要

Radiation effects on permeability of liposomes with different lipid compositions and the content ratios were investigated using X-rays. Liposomes constituted from an unsaturated phosphatidylcholine (PC), a saturated PC, and cholesterol were selected. As a result, we found that a PC with bis-allylic hydrogen, particularly dilinoleoyl PC (DLOPC), is essential for the radiation sensitivity in permeability, and it can be controlled by changing DLOPC content and dose rate. These characteristics are contributive to a novel pharmaceutical and a new-conceptual radiation dosimeter. ? 2013 Elsevier Ltd.
机译:用X射线研究了辐射对不同脂质组成和含量比脂质体通透性的影响。选择由不饱和磷脂酰胆碱(PC),饱和PC和胆固醇组成的脂质体。结果,我们发现具有双烯丙基氢的PC,特别是二亚油酰基PC(DLOPC),对于渗透率的辐射敏感性是必不可少的,并且可以通过更改DLOPC的含量和剂量率来控制。这些特征有助于新型药物和新概念的辐射剂量计。 ? 2013爱思唯尔有限公司

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