Improved Labeling Technique and Radiochemical Purity Determination of ↑(99m)Tc-N-acetylcysteine

摘要

A simple procedure for the labeling of N-acetylcysteine with ↑(99m)Tc and the results of optimization of the labeling procedure are described. The best results are obtained using 10 mg of the ligand and 26 μg of Sn(Ⅱ), at an alkaline pH. In these conditions, the radiochemical yield is found to be greater than 98%, with good reproducibility. The complex obtained is recommended for further studies in biological systems. # 1997 Elsevier Science Ltd