Balancing the Risks and Benefits of Extended Adjuvant Endocrine Therapy

摘要

Historically, it has been at least 5 years of adjuvant endocrine therapy. This recommendation was based on the meta-analysis from the Early Breast Cancer Trialists' Collaborative Group (EBCTCG), published in the Lancet, which found that treatment with 5 years of tamoxi-fen-based endocrine therapy resulted in both increases in disease-free survival and reductions in breast cancer mortality that lasted up to 15 years after the completion of endocrine therapy. As a result, that regimen has remained the standard for a long time.