Transmissible spongiform encephalopathy in the 21st century: neuroscience for the clinical neurologist.

摘要

There is no shortage of recent reviews on various aspects of transmissible spongiform encephalopathy (TSE),but none has been addressed to clinical neurologists in the hope of providing a reasonably brief and non-technical summary of the more important advances since the turn of the century. The beneficiary of opinions from members of both the basic and clinical research communities, this synopsis was undertaken to strike a readable compromise between the depths of specialized reviews and the shallows of abstracts generated by Internet search engines (PubMed lists 934 entries for Creutzfeldt-Jakob disease [CJD], 2,170 entries for TSE, and 4,729 entries for prion disease published since the turn of the century).