CSF analysis in suspected MS Do bands aid?

摘要

An initial attack of CNS demyelination is followed by uncertainty about whether conversion to multiple sclerosis (MS) will follow. MRI has some predictive value, but at the first attack stage fewer than 50% of patients fulfill the specific MRI criteria established for diagnosis of MS. Detection of intra-thecal IgG synthesis at presentation has been described as a predictive indicator of conversion to clinically definite MS in patients presenting with isolated brainstem, spinal cord, or optic nerve syndromes. Previous studies indicated that oligo-clonal band (OCB) testing has a high sensitivity and negative predictive value for future MS diagnosis. Most studies, however, do not include and interpret MRI data in parallel with CSF findings#