Polymorphism of the CAG trinucleotide repeat of exon 1 of the androgen receptor gene in the Tomsk population

摘要

Polymorphism of the CAG repeat of exon 1 of the androgen receptor (AR) gene was analyzed in the Tomsk population. In total, 12 alleles varying in size form 285 to 318 bp (21-32 CAG units) were revealed. The allele frequency distribution did not differ from the normal one. No difference in allele frequencies was detected between men and women of the same generation. The observed hterozygosity ws equal to the expected one (0.88 +- 0.03). compaed with other populations, the Tomsk population displayed a narrower allele spectrum and a bias of the most common allele to a greater repeat number. The results obtained may reflect specific population genetic processed characteristic of young developing populations.