Antibacterial activity of sponge extracts against fish pathogens

摘要

The antibacterial properties of organic extracts of 15 species of sponges collected from a depth of 30 m in the coastal waters off Gopalpur (Bay of Bengal) were tested against six virulent fish pathogens. The extracts of 11 sponges showed species-specific antibacterial activity. Four extracts exhibited broad antibacterial activity against three or more species. Epipolasis topsenti was active against all the six pathogens and showed the lowest minimum inhibitory concentration (MIC) value of 12.5 mug against three pathogens. Chromatographic fractionation of extracts yielded enriched fractions with increased activity and lower MIC values.