We read with interest the review by Franchini and Mannucci examining the link between exposure to particulate matter air pollution (PM) and an increased tendency toward thrombosis. In their discussion of the potential mechanisms by which PM might induce thrombosis, the investigators highlight the excellent work by Nemmar and colleagues suggesting that PM enhances the release of histamine by mast cells and the resulting activation of platelets increases the tendency toward thrombosis in hamsters administered intratracheal suspensions of diesel exhaust particles.2
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