Chronic GVHD: a new risk score?

摘要

Chronic GVHD is the leading cause of late nonrelapse morbidity and mortality. It is thus crucial for patient management and counseling to identify patients with low or high chronic GVHD-associated nonrelapse mortality risk.Chronic graft-versus-host disease (GVHD) is a frequent but highly polymorphic complication of allogeneic stem cell transplantation. Its clinical presentation varies from few lichenoid skin lesions to a highly aggressive disease with multiple organ involvement mimicking autoimmune diseases such as scleroderma. Since its first clinical description in 1980,1 clinicians have tried to characterize the disease severity to adapt treatments and predict outcomes. Several risk factors predicting survival in patients with chronic GVHD have been reported (reviewed in Lee et al2) but none of them really reached applicability in clinical practice. However, some presenting features have been repeatedly associated with poor outcomes.