Cost-effectiveness of solvent/detergent-treated fresh-frozen plasma.

摘要

BACKGROUND AND OBJECTIVES: Although transfusion-transmitted infections are rare, non-infectious complications occur relatively frequently. Solvent/detergent-treated fresh-frozen plasma (SD-FFP) has been shown to reduce the frequency of both types of complication, although previous economic evaluations failed to consider non-infective events and subsequently underestimated the benefits of SD-FFP. MATERIALS AND METHODS: A time-series analytical model was used to estimate the incremental cost/life year saved for SD-FFP compared with untreated FFP, having controlled for post-transfusion mortality and patient age. Various infective and non-infective transfusion-related complications were considered. RESULTS: The discounted cost/life year saved for SD-FFP use in the UK was pound 22 728 [95% confidence interval (95% CI): pound 22 604-22 853] for neonates and pound 98 465 (95% CI: pound 97 924-99 005) for patients aged 70. The cost-effectiveness ratio was below pound 50 000/life year saved for patients